pms-Irbesartan Dosage/Direction for Use

Dosing Considerations: Initiation of therapy requires consideration of recent antihypertensive drug treatment, the extent of blood pressure (BP) elevation, salt restriction, and other pertinent clinical factors. The dosage of other antihypertensive agents used with pms-IRBESARTAN (irbesartan) may need to be adjusted.
Recommended Dose and Dosage Adjustment: Essential Hypertension: The recommended initial dose of pms-IRBESARTAN is 150 mg once daily. In patients whose BP is not adequately controlled, the daily dose may be increased to 300 mg.
Essential Hypertension with Type 2 Diabetic Renal Disease: The recommended initial dose of pms-IRBESARTAN is 150 mg once daily. In patients whose BP is not adequately controlled, the daily dose may be increased to 300 mg once daily, the preferred maintenance dose.
Geriatrics: No initial dosage adjustment is required in the elderly (see Pharmacology: Pharmacokinetics: Special Populations and Conditions under Actions; and Precautions).
Renal Insufficiency: No initial dosage adjustment is required in patients with renal impairment (see Pharmacology: Pharmacokinetics: Special Populations and Conditions under Actions). However, due to the apparent greater sensitivity of hemodialysis patients, an initial dose of 75 mg is recommended in this group of patients.
Hepatic Insufficiency: No initial dosage adjustment is required in patients with mild-to-moderate hepatic impairment (see Pharmacology: Pharmacokinetics: Special Populations and Conditions under Actions).
Concomitant Diuretic Therapy: In patients receiving diuretics, pms-IRBESARTAN therapy should be initiated with caution, since these patients may be volume-depleted and thus more likely to experience hypotension following initiation of additional antihypertensive therapy. Whenever possible, all diuretics should be discontinued 2 - 3 days prior to the administration of pms-IRBESARTAN to reduce the likelihood of hypotension (see Cardiovascular under Precautions; and Interactions). If this is not possible because of the patient's condition, pms-IRBESARTAN should be administered with caution and the blood pressure monitored closely. The recommended starting dose of pms-IRBESARTAN is 75 mg once daily in hypovolemic patients (see Cardiovascular under Precautions). Thereafter, the dosage should be adjusted according to the individual response of the patient.
Administration: pms-IRBESARTAN may be administered with or without food.
Missed Dose: Patients should be instructed to take pms-IRBESARTAN at the next scheduled dose and not take two doses at the same time if they miss a dose.