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Patients with severe liver impairment should be administered a lower initial dose because they may have reduced clearance of loratadine; an initial dose of 5 mg once daily or 10 mg every other day is recommended.
Use in pregnancy and lactation: Safe use of loratadine during pregnancy has not been established; therefore, use only if potential benefit justifies potential risk to the foetus.
Since loratadine is excreted in breast milk and because of the increased risk of antihistamines for infants, particularly newborns and premature infants, a decision should be made whether to discontinue nursing or discontinue the drug.
Use in Children: The safety and effectiveness of loratadine in paediatric patients under 6 years of age have not been established.
