Pentacarinat Caution For Usage

Special precautions for disposal: This product should be reconstituted in a fume cupboard. Store the dry product below 25°C. Store dilute reconstituted drug solutions between 2-8°C, and discard all unused portions within 24 hours of preparation. Concentrated solutions for administration by the inhalation or intramuscular routes should be used immediately.
After reconstitution with Water for Injections, pentacarinat should not be mixed with any injection solutions other than Glucose Intravenous Infusion 5% and 0.9% (normal) Sodium Chloride Injection.
The optimal particle size for alveolar deposition is between 1 and 2 microns.
The freshly prepared solution should be administered by inhalation using a suitable nebuliser such as a Respirgard II (trade mark of Marquest Medical Products Inc.), Modified Acorn system 22 (trade mark of Medic-Aid) or an equivalent device with either a compressor or piped oxygen at a flow rate of 6 to 10 Litres/Minute.
The nebuliser should be used in a vacated, well ventilated room. Only staff wearing adequate protective clothing (mask, goggles, gloves) should be in the room when nebulisers are being used.
A suitable well fitted one-way system should be employed such that the nebuliser stores the aerosolised drug during exhalations and disperses exhaled pentamidine into a reservoir. A filter should be fitted to the exhaust line to reduce atmospheric pollution. It is advisable to use a suitable exhaust tube which vents directly through a window to the external atmosphere. Care should be taken to ensure that passers-by will not be exposed to the exhaust. All bystanders including medical personnel, women of child bearing potential, pregnant women, children, and people with a history of asthma, should avoid exposure to atmospheric pentamidine resulting from nebuliser usage.
Dosage equivalence: 4 mG of pentamidine diisetionate contains 2.3 mG pentamidine base; 1 mg of pentamidine base is equivalent to 1.74 mG pentamidine diisetionate.
Displacement value: 300 mG of pentamidine diisetionate displace approximately 0.15 ml of water.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.