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Oxymetazoline hydrochloride is a sympathomimetic drug which acts as a topical decongestant by stimulating the L-adrenergic receptors of the vascular smooth muscle, constricting the dilated arteriolar network within the nasal mucosa and reducing blood flow in the engorged edematous nasal area. The constriction results in shrinkage of the engorged mucous membranes, which promotes drainage, improves nasal ventilation and relieves the feeling of stuffiness.
Pharmacology: Oxymetazoline hydrochloride is a sympathomimetic amine with L-receptor action. It caused marked vasoconstriction and blanching when applied to nasal and pharyngeal mucosal surfaces. Sufficient absorption may cause central nervous system depression, leading to coma and marked reduction in body temperature especially in infants. Oxymetazoline hydrochloride is a long acting topical nasal decongestant. It acts within a few minutes and the effect up to 12 hours.
