Nitrolingual Side Effects

Like all medicines, Nitrolingual Spray can cause side effects, although not everybody gets them.
The following frequency statements are used for evaluating side effects: Very common (more than 1 in 10 patients treated); Common (1 to 10 in 100 patients treated); Uncommon (1 to 10 in 1,000 patients treated); Rare (1 to 10 in 10,000 patients treated); Very rare (less than 1 in 10,000 patients treated); Not known (frequency cannot be estimated from the available data).
Common: Headache ("nitrate-induced headache") may very commonly occur at the start of treatment; based on experience, this mostly wears off after a few days with continued intake.
A fall in blood pressure and/or orthostatic hypotension (a drop in blood pressure upon standing) is commonly observed during initial use or after a dose increase, and may be accompanied by an increase in pulse rate, drowsiness, as well as feeling dizzy and weak.
Uncommon: Sharp drop in blood pressure with increased chest pain (angina symptoms); States of collapse, often with heart rhythm disorders together with a slow pulse rate and sudden loss of consciousness; Nausea, vomiting; Facial redness; Allergic reactions, such as skin reactions and, in isolated cases, swelling of the tongue.
Very rare: Severe inflammatory skin disease (exfoliative dermatitis); Reduced blood flow to tissue sections of the brain (cerebral ischaemia); Impaired breathing; Restlessness.
Not known: A decrease in effectiveness (tolerance development) and a weakening of the drug effect have been described during previous treatment with other nitrate medicines. To prevent any weakening or loss of effect, constantly high dosages should be avoided.
Other possible side effects: Peppermint oil can trigger hypersensitivity reactions (including shortness of breath) in sensitised patients.
Other information: When Nitrolingual Spray is administered, there may be a temporary reduction in oxygen levels in arterial blood, due to a relative redistribution of blood flow into underventilated areas of the lung. In patients with coronary artery disease, this may trigger a decrease in oxygen supply to heart muscle.
Reporting of side effects: If patients get any side effects, they should seek medical advice. This includes any possible side effects not listed previously. By reporting side effects, patients can help provide more information on the safety of this medicine.