Mezavant XL Drug Interactions

Drug-drug interaction studies in healthy adult subjects have been conducted with Mezavant to investigate any effect of mesalazine on the pharmacokinetics and safety of three commonly used antibiotics. There were no clinically significant interactions of mesalazine with amoxicillin, metronidazole or sulfamethoxazole.
However, the following drug-drug interactions have been reported for products containing mesalazine.
Caution is recommended for the concomitant use of mesalazine with known nephrotoxic agents, including non-steroidal anti-inflammatory drugs (NSAIDs) and azathioprine, as these may increase the risk of renal adverse reactions.
Mesalazine inhibits thiopurine methyltransferase. In patients receiving azathioprine or 6-mercaptopurine and/or any other active substances known to cause myelotoxicity, caution is recommended for concurrent use of mesalazine as this can increase the potential for blood dyscrasias, bone marrow failure, and associated complications (see Precautions and Adverse Reactions).
Administration with coumarin-type anticoagulants, e.g. warfarin, could result in decreased anticoagulant activity. Prothrombin time should be closely monitored if this combination is essential.
Mezavant is recommended to be administered with food (see Dosage & Administration and Pharmacology: Pharmacokinetics under Actions).