Mezavant XL Dosage/Direction for Use

Mezavant XL is intended for once daily oral administration. The tablets must not be crushed or chewed and should be taken with food.
Adults, including the elderly (>65 years): For induction of remission: 2.4 g to 4.8 g (two to four tablets) should be taken once daily. The highest dose of 4.8 g/day is recommended for patients not responding to lower doses of mesalazine. When using the highest dose (4.8 g/day), the effect of the treatment should be evaluated at 8 weeks.
For maintenance of remission: 2.4 g (two tablets) should be taken once daily.
Children and adolescents (weighing more than 50 kg and age 10 years or older): For induction of remission (initial 8 weeks): 2.4 g to 4.8 g (two to four tablets) should be taken once daily.
For maintenance of remission: 2.4 g (two tablets) should be taken once daily.
Mesalazine 1200 mg tablets should not be used by paediatric patients weighing 50 kg or less and should not be used in paediatric patients below the age of 10 years due to a lack of data on safety and efficacy in these patients.
Hepatic and renal impairment: Specific studies have not been performed to investigate mesalazine in patients with hepatic or renal impairment (see Contraindications and Precautions).