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Mag-Tab SR caplets are available as white, oblong shaped caplets.
Each caplet contains magnesium L-lactate dihydrate 84 mg, or 7 mEq of elemental magnesium, in a sustained release formulation.
Chemistry: Magnesium L-lactate dihydrate is a white crystalline powder that is soluble in water: one gram dissolves in 25 mL cold water, 3.5 mL boiling water; it is slightly soluble in alcohol. The aqueous solution is slightly acidic.
Magnesium L-lactate is stable at room temperature, normal lighting and humidity. Mag-Tab SR caplets have expiration dates of at least 48 months when stored at recommended controlled room temperatures of 15° to 30°C (59° to 86°F).
The empirical formula is Mg(C3H5O3)2·2H2O and the molecular weight is 238.47.
Release Characteristics: The Mag-Tab SR continuous release formulation provides maximum absorption and bioavailability at the pH of the ileum and jejunum where the majority of magnesium is absorbed; and it minimizes the gastrointestinal side effects (e.g. cramping, diarrhea) seen with other formulations. The lactate anion is better absorbed than other Mg++ salts and it is not associated with a cathartic effect. The formulation is a continuous release, rather than an immediate release, which feature improves the absorption process, and thus intraluminal concentrations of the released salt are kept to a minimum.
In addition, the continuous release formulation provides another important property: the transient rise of serum M++ after oral supplementation represents a pool of Mg available for redistribution into tissue. Renal excretion competes against tissue uptake for redistribution of serum Mg++. The healthy kidney efficiently excretes excess Mg++. An immediate release formulation is associated with increased renal clearance relative to tissue redistribution because of a rapid influx of absorbed Mg++, leading to a spike in serum Mg++ concentrations. The Mag-Tab SR continuous release formulation facilitates a slower absorption pattern, which enables tissue redistribution to compete more effectively against renal excretion.
Excipients/Inactive Ingredients: Polyethylene glycol, microcrystalline cellulose, carnauba wax, stearic acid, calcium stearate, and Opadry 11 White.
