Lomac-20 Dosage/Direction for Use

Lomac should be taken before meals.
Patients should be cautioned that the Lomac capsules should not be opened, chewed or crushed and should be swallowed whole.
Duodenal ulcers, gastric ulcers and reflux oesophagitis. The recommended dosage is one capsule of Lomac (20 mg) once daily.
In patients with duodenal ulcers symptom relief is rapid and healing occurs within 2 weeks in most cases. For those patients who may not have fully healed after the initial course, healing usually occurs during a further 2 weeks treatment period.
In patients with gastric ulcers and reflux oesophagitis symptom relief is rapid and healing occurs within 4 weeks in most cases.
For those patients who may not have fully healed after the initial course healing usually occurs during a further 4 weeks treatment period.
In patients refractory to other treatment regiments, 2 capsules of Lomac (40 mg) once daily has been used and healing achieved usually within 4 weeks in patients with duodenal ulcer and within 8weeks in patients with gastric ulcers or reflux oesophagitis.
Zollinger-Ellison syndrome: The recommended initial dosage is 3 capsules of Lomac (60 mg) once daily. The dosage should be adjusted individually and treatment continued as long as is clinically indicated. All patients with severe disease and inadequate response to other therapies have been effectively controlled and more than 90% of patients maintained on the doses of 20-120 mg daily. With doses above 80 mg daily, the dose should be divided and given twice daily.
Impaired renal and liver function: No dosage adjustments is required in patients with impaired renal or liver function and in the elderly.
Eradication of Helicobacter pylori: Lomac may be combined with antibacterials in dual or triple therapy. Effective triple therapy regimens include Lomac 20 mg twice daily combined with: Amoxicillin 500 mg and metronidazole 400 mg, both three times daily: clarithromycin 500 mg and metronidazole 400 mg (or tinidazole 500 mg) both twice daily; or with Amoxicillin 1 g and clarithromycin 500 mg both twice daily. These regimens are given for 1 week.
Dual therapy regimens such as Lomac 40 mg daily with either amoxicillin 750 mg to 1 g twice daily or clarithromycin 500 mg three times daily, are less effective and must be given for 2 weeks. Omeprazole alone may be continued for a further 2 to 8 weeks.
Treatment and Prevention of NSAID-associated Ulceration: Doses of 20 mg daily are used in the treatment of NSAID-associated ulceration: a dose of 20 mg daily may also be used for prophylaxis in patients with a previous history of gastroduodenal lesions who require continued NSAID treatment.