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Like all medicines, this medicine can cause side effects, although not everybody gets them. Many of the side effects can be relieved by adjusting the dose.
If the following symptoms are experienced during treatment with Levodopa/Carbidopa/Entacapone Teva Tablets, contact the doctor immediately: Muscles get very rigid or jerk violently, or tremors, agitation, confusion, fever, rapid pulse, or wide fluctuations in blood pressure occur [these can be symptoms of neuroleptic malignant syndrome (NMS, a rare severe reaction to medicines used to treat disorders of the central nervous system) or rhabdomyolysis (a rare severe muscle disorder)]; Allergic reaction, the signs may include hives (nettle rash), itching, rash, swelling of face, lips, tongue or throat [this may cause difficulties in breathing or swallowing].
Very common (may affect more than 1 in 10 people): uncontrolled movements (dyskinesias); feeling sick (nausea); harmless reddish-brown discoloration of urine; muscle pain; diarrhoea.
Common (may affect up to 1 in 10 people): lightheadedness or fainting due to low blood pressure, high blood pressure; worsening of Parkinson's symptoms, dizziness, drowsiness; vomiting, abdominal pain and discomfort, heartburn, dry mouth, constipation; inability to sleep, hallucinations, confusion, abnormal dreams (including nightmares), tiredness; mental changes including problems with memory, anxiety and depression (possibly with thoughts of suicide); heart or artery disease events (e.g. chest pain), irregular heart rate or rhythm; more frequent falling; shortness of breath; increased sweating, rashes; muscle cramps, swelling of legs; blurred vision; anaemia; decreased appetite, decreased weight; feeling of weakness, fatigue; abnormal gait; headache, joint pain; urinary tract infection.
Uncommon (may affect up to 1 in 100 people): heart attack; bleeding in the gut; changes in blood cell count which may result in bleeding, abnormal liver function tests; convulsions; feeling agitated; psychotic symptoms; colitis (inflammation of the colon); discolourations other than urine (e.g. skin, nail, hair, sweat); swallowing difficulties; inability to urinate; feeling unwell.
The following side effects have also been reported: hepatitis (inflammation of the liver); itching.
The following side effects may be experienced: Craving for large doses of Levodopa/Carbidopa/Entacapone Teva Tablets in excess of that required to control motor symptoms, known as dopamine dysregulation syndrome [some patients experience severe abnormal involuntary movements (dyskinesia), mood swings or other side effects after taking large doses of Levodopa/Carbidopa/Entacapone Teva Tablets]; Inability to resist the impulse to perform an action that could be harmful, which may include strong impulse to gamble excessively despite serious personal or family consequences, altered or increased sexual interest and behaviour of significant concern (for example, an increased sexual drive), uncontrollable excessive shopping or spending, binge eating (eating large amounts of food in a short time period) or compulsive eating (eating more food than normal and more than is needed to satisfy hunger).
Tell the doctor if any of these behaviours are experienced; they will discuss ways of managing or reducing the symptoms.
Reporting of side effects: If any side effects are experienced, talk to the doctor, pharmacist or nurse. This includes any possible side effects not previously listed. By reporting side effects, more information can be provided on the safety of this medicine.
