Latachimo Combination Description

Composition and Description: See Table 1.

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Physicochemistry of Active Ingredient: Latanoprost: Latanoprost is colorless to pale yellow and viscous oil. It is very soluble in acetonitrile and N,N-dimethylacetamide, freely soluble in ethanol (99.5), ethyl acetate, isopropanol, methanol, acetone, and octanol. It is practically insoluble in water.
Nonproprietary name: Latanoprost.
Chemical name: (+)-Isopropyl(Z )-7-[(1R, 2R, 3R, 5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate.
Molecular formula: C₂₆H₄₀O₅.
Molecular weight: 432.59.
Timolol Maleate: Timolol Maleate occurs as a white to pale yellow-white crystalline powder. It is freely soluble in acetic acid (100), and soluble in water and in ethanol (99.5). It dissolves in 0.1 mol/L hydrochloric acid test solution.
Nonproprietary name: Timolol Maleate.
Chemical name: (2S)-1-[(1,1-Dimethylethyl)amino]-3-(4-morpholin-4-yl-1,2,5-thiadiazol-3-yloxy)propan-2-ol monomaleate.
Molecular formula: C₁₃H₂₄N₄O₃S・C₄H₄O₄.
Molecular weight: 432.49.
Melting point: about 197°C (with decomposition).