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This product is contraindicated in the following patients: Patients with active or a history of bronchial asthma, bronchospasm, and severe chronic obstructive pulmonary disease. [Asthmatic attack may be induced or exacerbated by bronchial smooth muscle contractions due to β-receptor blockade.]
Patients with poorly controlled heart failure, sinus bradycardia, and second or third degree atrioventricular block, and cardiogenic shock. [These symptoms may be exacerbated by negative chronotropic/inotropic effects due to β-receptor blockade.]
Patient with known hypersensitivity to latanoprost and timolol maleate or any other component of this product.
