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Irbegen Plus should not be taken in case of: allergy to irbesartan or any of the other ingredients of this medicine (listed in Description); allergy to hydrochlorothiazide or any other sulfonamide-derived medicines; pregnancy of more than 3 months (Irbegen Plus should be avoided in early pregnancy, see Use in Pregnancy & Lactation); severe liver or kidney problems; difficulty in producing urine; persistently high calcium or low potassium levels in the blood; diabetes or impaired kidney function and treatment with a blood pressure lowering medicine containing aliskiren.
The concomitant use of Irbegen Plus with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2).
