General Precautions: Since it was reported that symptoms were aggravated after the sudden withdrawal of calcium-antagonist medication, the dose should be reduced gradually and the symptoms should be carefully observed if Herbesser 30/Herbesser 60 are to be withdrawn. Patients should be given precautions not to discontinue Herbesser 30/Herbesser 60 medication without a physician's direction.
Herbesser 30/Herbesser 60 are to be carefully administered to patients with severe bradycardia (<50 bpm) or with 1st-degree atrioventricular block.
Use in pregnancy & lactation: Since animal experiments have proven the teratogenic and feticidal effects of diltiazem HCl, the administration of Herbesser 30/Herbesser 60 is contraindicated to pregnant women and women suspected of being pregnant.
It is not recommended to administer Herbesser 30/Herbesser 60 to nursing mothers since it was reported that diltiazem HCl was excreted in human milk. If administration is necessitated, nursing should be avoided.
Use in children: The safety of Herbesser 30/Herbesser 60 in children has not been established.
Use in the elderly: Since excessive lowering of blood pressure is undesirable for the elderly, it is advisable to start with a low dose, and Herbesser 30/Herbesser 60 should be administered under careful supervision.