Freenos SR Overdosage

In the event of overdosage, treatment, which should be started immediately, is symptomatic and supportive. Discontinuation of use, gastric lavage and support of vital functions are advised.
Manifestations: They may vary from CNS depression (sedation, apnea, diminished mental alertness, cyanosis, coma, cardiovascular collapse) to stimulation (insomnia, hallucination, tremors, or convulsions) to death. Other signs and symptoms may be euphoria, excitement, tachycardia, palpitations, thirst, perspiration, nausea, dizziness, tinnitus, ataxia, blurred vision and hypertension or hypotension. Stimulation is particularly likely in children, as are atropine-like signs and symptoms (dry mouth; fixed, dilated pupils; flushing; hyperthermia; and gastrointestinal symptoms).
In large doses sympathomimetics may give rise to giddiness, headache, nausea, vomiting, sweating, thirst, tachycardia, precordial pain, palpitations, difficulty in micturition, muscular weakness and tenseness, anxiety, restlessness, and insomnia. Many patients can present a toxic psychosis with delusions and hallucinations. Some may develop cardiac arrhythmias, circulatory collapse, convulsions, coma, and respiratory failure.
Treatment: Emergency treatment should be started immediately. There is no specific antidote. Treatment of overdosage consists of single-dose activated charcoal. Use should be considered in a patient who presents within 1 hour of ingestion. Activated charcoal is contraindicated in a patient with diminished level of consciousness unless airway is protected. In some rare situations, gastric lavage may be appropriate if initiated within 1 hour of ingestion, though this technique has not been proven to be beneficial and is thus rarely used due to risks of complications and lack of efficacy. Its use is contraindicated in patients with unprotected airways, in patients where use would increase risk and severity of aspiration, and in patients at risk of hemorrhage or GI perforation. Ipecac has not been shown to be beneficial based on experimental and clinical studies.
Loratadine is not cleared by hemodialysis to any appreciable extent. It is not known if loratadine is removed by peritoneal dialysis.
After emergency treatment, the patient should continue to be medically monitored. Treatment of the signs & symptoms of overdosage is symptomatic and supportive. Stimulants (analeptic agents) should not be used. Vasopressors may be used to treat hypotension. Short-acting barbiturates, diazepam or paraldehyde may be administered to control seizures. Hyperpyrexia, especially in children, may require treatment with tepid water sponge baths or hypothermic blanket. Apnea is treated with ventilatory support.