Fluconazole Stella Use In Pregnancy & Lactation

Pregnancy: A few published case reports describe a rare pattern of distinct congenital anomalies in infants exposed in-utero to high-dose maternal fluconazole (400-800 mg/day) during most or all of the first trimester. These reported anomalies are similar to those seen in animal studies. If this drug is used during pregnancy, or if the patient becomes pregnant while taking the drug, the patient should be informed of the potential hazard to the fetus.
Studies in animals have shown reproductive toxicity.
Fluconazole in standard doses and short-term treatments should not be used in pregnancy unless clearly necessary.
Fluconazole in high doses and/or in prolonged regimens should not be used during pregnancy except for potentially life-threatening infections.
Lactation: Fluconazole passes into breast milk to reach concentrations similar to those in plasma. Breast-feeding may be maintained after a single dose of 150 mg fluconazole. Breast-feeding is not recommended after repeated use or after high-dose fluconazole. The developmental and health benefits of breast-feeding should be considered along with the mother's clinical need for fluconazole and any potential adverse effects on the breast-fed child from fluconazole or from the underlying maternal condition.