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Hypersensitivity to the active substance, to related azole substances, or to any of the excipients in the product.
Co-administration of terfenadine is contraindicated in patients receiving fluconazole at multiple doses of 400 mg per day or higher based upon results of a multiple-dose interaction study. Co-administration of other medicinal products known to prolong the QT interval and which are metabolised via the cytochrome P450 (CYP) 3A4, such as cisapride, astemizole, pimozide, quinidine and erythromycin, are contraindicated in patients receiving fluconazole.
