Fentanyl Martindale Drug Interactions

Other medicines and Fentanyl 50 micrograms/ml Solution for Injection: Concomitant use of fentanyl and sedative medicines such as benzodiazepines or related drugs increases the risk of drowsiness, difficulties in breathing (respiratory depression), coma and may be life-threatening. Because of this, concomitant use should only be considered when other treatment options are not possible. However, if fentanyl is prescribed together with sedative medicines, the dose and duration of concomitant treatment should be limited. Take note of all sedative medicines being taken by the patient. Ensure that the patient follows dose recommendation closely. It could be helpful to inform friends or relatives to be aware of the signs and symptoms previously stated. Be aware when the patient is experiencing such symptoms. Exercise caution if the patient is using or has recently used or might use any other medicines, including medicines obtained without a prescription.
Fentanyl Injection must not be used with Monoamine Oxidase Inhibitors (MAOIs), such as phenelzine or moclobemide, or if their intake has been stopped within the last 2 weeks.
Exercise caution if the patient: is taking Selective Serotonin Reuptake Inhibitors (SSRIs) or Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) for depression (such as citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine); is taking any major tranquilizer (antipsychotic) drug.
Medicines which may interact with Fentanyl Injection include: CNS depressants, including sleeping pills, antihistamines that cause drowsiness, medicines used to treat certain mental disorders, other painkillers or a general anaesthetic such as etomidate; ritonavir and other protease inhibitors such as indinavir and saquinavir; droperidol; muscle relaxants; antifungal medicines such as fluconazole or voriconazole; midazolam.
The dose of etomidate and midazolam may need to be reduced if given together with Fentanyl Injection.
Fentanyl Injection may increase the effects of the previously mentioned drugs or prevent them from working properly if they are being concomitantly taken.
Using Fentanyl Injection with food, drink and alcohol: The patient should not drink alcohol during treatment with Fentanyl Injection.