Entresto Description

50 mg: Violet white ovaloid biconvex film-coated tablet with beveled edges, unscored, debossed with "NVR" on one side and "LZ" on the other side.
Entresto film coated tablets contains 50 mg (24.3 mg sacubitril/25.7 mg valsartan)*.
100 mg: Pale yellow ovaloid biconvex film-coated tablet with beveled edges, unscored, debossed with "NVR" on one side and "L1" on the other side.
Entresto film coated tablets contains 100 mg (48.6 mg sacubitril/51.4 mg valsartan)*.
200 mg: Light pink ovaloid biconvex film-coated tablet with beveled edges, unscored, debossed with "NVR" on one side and "L11" on the other side.
Entresto film coated tablets contains 200 mg (97.2 mg sacubitril/102.8 mg valsartan)*.
*Information may differ in some countries.
Active substances: Sacubitril/Valsartan Sodium salt complex equivalent to sacubitril/valsartan anhydrous acid.
Entresto contains a salt complex of the anionic forms of sacubitril and valsartan, sodium cations, and water molecules in the molar ratio of 1:1:3:2.5 respectively. The empirical formula of the complex (hemipentahydrate) is C₄₈H₅₅N₆O₈Na₃ 2.5 H₂O. Its molecular mass is 957.99.
Following oral administration, the complex dissociates into sacubitril (which is further metabolized to sacubitrilat) and valsartan.
Excipients/Inactive Ingredients: Microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate (vegetable origin), talc and colloidal silicon dioxide.
Excipients of film coating: Hypromellose, titanium dioxide (E171), Macrogol 4000, talc, iron oxide red (E172).
For 50 and 200 mg: Iron oxide black (E172).
For 100 mg: Iron oxide yellow (E172).