Enspryng Special Precautions

Patients should seek medical attention immediately if the patient experiences any allergic reaction (see Side Effects).
Before taking Enspryng, caution should be exercised in case of taking, have recently taken or might take any other medicines such as warfarin, carbamazepine, phenytoin and theophylline as doses might need to be adjusted.
Infections: Enspryng cannot be used on patients with infection. Caution should be exercised in case of signs of infection before, during, or after Enspryng treatment such as: fever or chills; cough that does not go away; sore throat; cold sore or genital sores (herpes simplex); shingles (herpes zoster); skin redness, swelling, tenderness or pain; feeling or being sick, diarrhoea or belly pain.
This information can also be found in the patient alert card. Patients must be advised that the alert card should be kept at all times.
The infection should be controlled before giving the Enspryng or allowing the patient to continue to inject Enspryng.
Vaccinations: Before Enspryng administration, caution should be exercised in case of any vaccine given recently or might be given in the near future.
The need to administer any vaccines before starting Enspryng should be checked.
Live or live attenuated vaccines should not be administered (for example BCG for tuberculosis or vaccines against yellow fever) while being treated with Enspryng.
Liver enzymes: Enspryng can have effects on the liver and increase the amount of some liver enzymes in the blood. Blood tests should be done before the patient is given Enspryng, and during the treatment, to check how well the liver is working. Urgent medical advice or treatment may be needed in case of signs of liver damage during or after Enspryng treatment: yellowing of the skin and the whites of the eyes (jaundice); dark-coloured urine; feeling and being sick; abdominal pain.
White blood cell count: Blood tests should be performed before the patient is given Enspryng, and during the treatment, to check the patient's white blood cell count.
Driving and using machines: Enspryng is not likely to affect the ability to drive, cycle or use any tools or machines.
Use in Children: This medicine should not be given to children under 12 years of age. This is because it has not yet been studied in this age group.
Use in Pregnancy & Lactation: See USE IN PREGNANCY & LACTATION section for further information.