Babies born following very prolonged rupture of the membranes (higher than 3 weeks) may not show optimal response to the exogenous surfactant. Surfactant administration can be expected to reduce the severity of RDS or the risk of its occurrence, but cannot be expected to completely eliminate mortality and morbidity associated with preterm birth, as preterm babies may be exposed to other complications due to their immaturity. The administration of CUROSURF to premature infants with renal or hepatic impairment has not been studied.
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