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Strictures in the ileocaecal region and the ascending colon (fibrosing colonopathy) have been reported in cystic fibrosis patients receiving high doses of pancreatin preparations. As a precautionary measure, medical advice should be sought in the event of unusual abdominal discomfort or a change in the clinical picture in order to rule out the possibility of fibrosing colonopathy. This applies in particular to patients taking over 10,000 Ph. Eur. lipase units per kg body weight per day.
Effects on ability to drive and use machines: Creon has no effect or a negligible effect on the ability to drive and use machines.
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