Creon 10000 Dosage/Direction for Use

Dosage: The dosage depends on the individual requirements and the severity of pancreatic insufficiency and the composition of the meal.
Dosage in children: In children aged under 4 years the weight-based dose should begin with 1,000 Ph.Eur. lipase units/kg body weight/meal, in children over 4 years with a dose of 500 Ph.Eur lipase units/kg body weight/meal.
Dose for adolescents and adults: The dose should be adjusted for the individual patient, depending on the severity of the maldigestion and the fat content of the meal. As a general guide dose a lipase content per meal of between 20,000 and 80,000 Ph.Eur units (corresponding to 2 to 8 capsules of Creon 10000 capsules) is recommended. The required dose may however be considerably higher depending on the severity of the digestion weakness.
Recommended maximum daily dose: Particularly in patients with cystic fibrosis the dose taking into account the quantity and composition of the meals should not exceed the enzyme dose necessary for adequate fat absorption. The dose should only be increased under medical supervision and should aim at improving the symptoms (e.g. steatorrhoea, abdominal pain).
A daily enzyme dose of 15,000-20,000 PH. Eur. Lipase units/kilogram body weight or of 4,000 PH. Eur. Lipase units/gram of fat intake should not be exceeded.
Method of administration: The capsules should be taken unopened and without chewing with or immediately after a meal or a snack with sufficient fluid. Should it be difficult to swallow the capsules (e.g. small children, elderly patients), the capsules may be carefully opened and the pellets added to soft food (pH<5.5), which does not require chewing (e.g. apple puree) or the pellets may be taken with sufficient fluid.
All mixtures of pellets with food or fluids should be used immediately and not stored. Crushing or chewing the pellets or mixing with food or fluids with a pH higher than 5.5 may destroy the gastro-resistant coating of the pellets. As a result the enzymes may be released prematurely in the oral cavity, their efficacy reduced, and the mucous membrane there damaged. Care should be taken that no product residues remain in the oral cavity. Make sure sufficient fluid is taken.