Carboplatin-Tranet Caution For Usage

Handling of carboplatin: As with other antineoplastic agents, carboplatin must be prepared and handled with caution. The following protective measures should be taken when handling carboplatin. Personnel should be trained in appropriate techniques for reconstitution and handling.
1. Carboplatin should be prepared for administration only by professionals who have been trained in the safe use of chemotherapeutic agents. Personnel handling Carboplatin Infusion should wear protective clothing: goggles, gowns and disposable gloves and masks.
2. A designated area should be defined for syringe preparation (preferably under a laminar flow system), with the work surface protected by disposable, plastic-backed, absorbent paper.
3. All items used for reconstitution, administration or cleaning (including gloves) should be placed in high-risk, waste-disposal bags for high temperature incineration.
4. Spillage or leakage should be treated with dilute sodium hypochlorite (1% available chlorine) solution, preferably by soaking, and then water. All contaminated and cleaning materials should be placed in high-risk, waste-disposal bags for incineration. Accidental contact with the skin or eyes should be treated immediately by copious lavage with water, or soap and water, or sodium bicarbonate solution. However, do not abrade the skin by using a scrub brush. Medical attention should be sought. Always wash hands after removing gloves.
Preparation of infusion solution: The product must be diluted before use. It may be diluted with 5% Glucose or 0.9% Sodium Chloride, to concentrations as low as 0.5 mg/ml (500 micrograms/ml).
Disposal: Medicines should not be disposed of via wastewater or household waste. All material used for preparation, administration or otherwise coming into contact with carboplatin should undergo disposal according to local guidelines for the handling of cytotoxic compounds.
Incompatibilities: Carboplatin may interact with aluminium to form a black precipitate. Needles, syringes, catheters or intravenous sets containing aluminium parts that may come into contact with carboplatin should not be used for preparation or administration of drug. Precipitation can lead to a reduction of the antineoplastic activity.