Betadine Antiseptic Drug Interactions

Patients must be advised to inform the doctor or pharmacist if they are using, have recently used or might use any other medicines.
The concomitant use of wound-treatment preparations containing enzymatic component, hydrogen peroxide, silver and taurolidine leads to a weakening of the effects of both substances. Products containing mercury, silver, hydrogen peroxide, and taurolidine may interact with povidone-iodine and should not be used concomitantly. Simultaneous use with mercury products may lead to the formation of a substance, which can damage the skin.
Absorption of iodine from povidone-iodine or using this treatment may interfere with tests of thyroid function or radioiodine therapy and can make a planned treatment of the thyroid with iodine impossible. After the end of the treatment, 4 weeks (for Cream, Ointment and Surgical Scrub) and an interval of at least 1-2 weeks (for Dry Powder Spray) should be allowed before a new scintigram is carried out.
Several types of tests for detecting occult (not visible) blood in faeces or blood in urine may be affected (i.e. produce false-positive results), due to the oxidative effect of povidone-iodine preparations.
Transient dark discolorations may occur after the concomitant use with povidone-iodine products or before or after application use of octenidine containing antiseptics in the same or adjacent sites.
Povidone-iodine use could lead to transient skin discolouration at the application site caused by the drug product's own colour.
Cream: The PVP-iodine complex is effective at pH values of between 2.0 and 7.0. It has to be expected that the complex will react with protein and other unsaturated organic compounds, leading to impairment of its effectiveness.