ASP Drug Interactions

Treatment may be influenced if acetylsalicylic acid is administered concomitantly with the following medicines or medicines used in the treatment of the following conditions: Blood coagulation (e.g., warfarin); Selective serotonin reuptake inhibitors: the risk of gastrointestinal bleeding is increased; Pain and inflammation (e.g., steroids or anti-inflammatory agents); Corticosteroids: concomitant use with ASP 100 may increase the risk of gastrointestinal bleeding or ulceration; Diabetes (e.g., sulphonylureas); Gout (e.g., probenecid); Cancer or rheumatoid arthritis (e.g., methotrexate); Organ rejection after transplant (cyclosporin, tacrolimus); Sulphonylureas; Vatproic acid (used in the treatment of epilepsy); Insulin; Phenytoin; Triiodothyronine; Increased plasma digoxin concentrations (used in the treatment of heart failure), Barbiturates and lithium (used in the treatment of psychiatric disorders); Diuretics; Concomitant administration of ASP 100 decreases the effect of uricosuric agents (medicines that increase uric acid excretion) and alpha-interferon; Acetylsalicylic acid should never be administered simultaneously with live influenza virus vaccines.
Patients who have received a varicella virus (chickenpox) vaccine are advised not to take acetylsalicylic acid for 6 weeks after vaccination, since cases of a potentially severe disease (Reye's syndrome) have been observed following infection by the varicella virus.
Please tell the doctor if the patient is taking any other medicines before taking acetylsalicylic acid. If the patient takes acetylsalicylic acid on a regular basis, please seek medical advise before taking any other medicines (including medicines not subject to medical prescription).