If the patient is allergic (hypersensitive) to acetylsalicylic acid, other salicylates or any of the other ingredients of this medicine; If the patient has a history of gastrointestinal bleeding or perforations, related to previous NSAIDs therapy; If the patient suffers from peptic ulcer or has a history of recurrent peptic ulcer/bleeding or if the patient bleeds easily; During pregnancy; In children and adolescents younger than 16 years, with or without fever, given the risk of triggering a potentially severe disease (Reye's syndrome).