A-phine Special Precautions

Severe hypotensive patients; Renal impairment patients who needed dialysis.
Mild blood pressure depressant action occur after discontinuation because of long half-life. When other medication is administrated after discontinuation, dosage and interval should be administered cautiously.
As the drug effect is only gradually increased during onset period, it is not recommended to use the drug for unstable angina patients who needed emergent care.
Use in Patients with Congestive Heart Failure: Amlodipine has been compared to placebo in long term studies of patients with NYHA class III, IV heart failure. In these studies, there was no evidence of worsened heart failure.
Use in Patients with Hepatic Failure: The plasma elimination half-life (t_1/2) is extended in patients with impaired hepatic function. Caution should be exercised when administering amlodipine to patients with severe hepatic impairment.
Effects on Ability to Drive and Use Machine: Amlodipine doesn't reduce the ability of requiring mental alertness such as in operating a motor vehicle or other machine.
Use in Children: There is no established safety data for children.
Use in Elderly: The administration of general doses is recommended. Similar tolerance is showed in responses between the elderly and younger patients.