A-phine Adverse Reactions

Amlodipine is well-tolerated in most patients. Most common side effects which appeared in clinical trials with hypertension and angina patients are as follows: Autonomic Nervous System: Flushing.
General: fatigue.
Cardiovascular: edema.
Central and Peripheral Nervous System: vertigo, headache.
Gastrointestinal: abdominal pain, vomiting.
Heartbeat: tachycardia.
Psychiatric: Dizziness.
In patients who are in hospital care with heavy symptoms, Amlodipine has been associated as reported, but the relationship is not clear in most of cases.
The following postmarketing event has been reported infrequently.
Autonomic Nervous System: dry mouth, sweating increased.
General: asthenia, back pain, malaise, pain, weight gain, weight decrease.
Cardiovascular: hypotension, syncope.
Central and Peripheral Nervous System: hypoesthesia, neuropathy peripheral, paresthesia, tremor.
Endocrine: gynecomastia.
Gastrointestinal: constipation, dyspepsia, diarrhea, pancreatitis, vomiting, gingival hyperplasia.
Metabolic and Nutritional: hyperglycemia.
Musculoskeletal System: arthralgia, muscle cramps, myalgia.
Hemopoietic: purpura, thrombocytopenia.
Psychiatric: sexual dysfunction, insomnia, depersonalization.
Respiratory System: cough, dyspnea, rhinitis.
Skin and Appendages: depilation, skin discoloration, urticaria.
Special Senses: dysgeusia, tinnitus.
Urinary System: micturition frequency, micturition disorder, nocturia.
Vascular (exclude heart): angiitis.
Vision: abnormal vision.
Leukocyte / R.E.S: leukopenia.
Rarely allergic events such as pruritus, rash, angioedema, erythema multiforme, hepatitis, jaundice and hepatic enzyme elevations have been reported very rarely in association with mostly cholestasis. Some cases severe enough to require hospitalization have been reported in association with use of amlodipine.
The following adverse events have been reported infrequently where a causal relationship is uncertain with Myocardial infarction, arrhythmia, chest pain.
The following side effects have been reported.
Cardiovascular: occasionally blood pressure decrease, atrioventricular block and rarely abdominal dysphoria may occur.
Gastrointestinal: Occasionally abdominal pain, diarrhea, loose stools, constipation, etc. may occur.
Skin: Rarely maculopapular rash, etc. may occur.
Other: occasionally headache, fever sense, glucose intolerance decrease, sickness, etc. may occur.