The risk of orthostatic hypotension and syncope during treatment with risperidone can be minimized by limiting the initial dose to 1 mg twice daily for normal adults and 0.5 mg twice daily, for the elderly or debilitated, those with impaired renal or hepatic function and those prone to or at risk of hypotension.
In patients with cardiovascular disease (severe arteriosclerosis, heart failure, conduction disturbances), cerebrovascular disease, or conditions predisposed to hypotension (eg, dehydration, decreased blood flow, concomitant antihypertensive therapy) and in patients with a history of seizures, spasticity or Parkinson's syndrome, a lower dose should be used and treatment should be initiated at a low dose. Because risperidone can interfere with judgment, thinking and motor skills, patients should not operate hazardous machinery, including motor vehicles, until they are certain that risperidone is not causing the undesirable effects as previously mentioned. People with diabetes or people at high risk of diabetes (fat, family history of diabetes, etc) when taking any atypical drug including risperidone must closely monitor blood glucose.
People with Parkinson's syndrome or dementia taking antipsychotics including risperidone may increase their sensitivity to antipsychotics. Clinical manifestations: Confusion, loss of balance, easy to fall, extrapyramidal symptoms. Close monitoring is required.
Use with caution in patients with a history of convulsions.
Caution should be exercised when giving drugs to elderly people with dementia because of the risk of aspiration into the lungs.
Drugs used for children, must monitor weight, drugs that increase prolactin secretion. The manufacturer states that the long-term effects of risperidone on a child's development and maturation are not fully known.
Effects on Ability to Drive and Use Machines: Use caution when driving and using machines.