Đăng xuất
Pharmacology: Pharmacodynamics: Mometasone furoate is a synthetic glucocorticoid with anti-inflammatory activity. Corticosteroids inhibit many types of cells (eutrophic cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (histamine, eicosanoids, leukotriene, and cytokines) that are involved in inflammation and asthma. White blood cells and macrophages facilitate the initiation of these substance-mediated responses. Mometasone furoate inhibits the adhesion of leukocytes to the damaged vessel wall, which then prevents the inflammatory cells from migrating to the damaged area, constricting the vessels and reducing the permeability of blood vessels, resulting in the inflammatory cells not reaching the site of damage.
Pharmacokinetics: Mometasone furoate nasal spray has negligible systemic bioavailability (<=0.1%) and is generally undetectable in plasma, despite the use of a sensitive quantification with a low defined limit of 50 pg/ml; therefore, there are no corresponding pharmacokinetic data for this dosage form. Mometasone furoate suspension is very poorly absorbed by the gastrointestinal tract and a small amount can be swallowed and absorbed undergoing an extensive initial metabolism before being excreted in urine and bile.
