Giới thiệu
- Also known as chronic myelogenous, myelocytic, or chronic granulocytic leukemia
- Has three phases: Chronic, accelerated and blast
- Median age in Asian and African countries is <50 years old
- Median age in western countries at presentation is at >50 years old
Definition
- A myeloid disorder associated with Philadelphia (Ph) chromosome t(9;22)(q34;q11), a fusion of the breakpoint cluster region (BCR) and Abelson murine leukemia (ABL1) genes
Signs and Symptoms
- Systemic symptoms:
- Anemia
- Abdominal fullness
- Abdominal pain that may present with left upper quadrant pain and early satiety
- Bleeding episodes due to platelet dysfunction
- Fatigue
- Malaise
- Weight loss
- Other frequent findings:
- Splenomegaly
- Raised platelet count
- Increased white blood cell (WBC) count
- Involvement of lymph nodes, skin and soft tissue (patients with blast crisis)
Yếu tố nguy cơ
- The only known risk factor is exposure to ionizing radiation