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Concomitant administration of bisphosphonates including Zoledronic acid with aminoglycosides may result in lowering serum calcium concentration for prolonged period. Use concomitantly with caution.
Concomitant administration of Zoledronic acid with loop diuretics may increase risk of hypocalcemia. Use concomitantly with caution.
Concomitant administration of Zoledronic acid with nephrotoxic agents may cause hypomagnesemia and may increase risk of renal dysfunction. Interim monitoring of renal function should be considered between the initial and subsequent doses of Zoledronic acid.
Concomitant administration of Zoledronic acid with thalidomide in patients with multiple myeloma may potentiate risk of renal dysfunction.
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