Winsulin-N/Winsulin-30/70/Winsulin-R Mechanism of Action

Pharmacodynamics: Mechanism of Action: Like all other insulins, the glucose lowering effect of Insulin isophane insulin human suspension-NPH/Winsulin-30/70/Insulin human Regular is due to the facilitated uptake of glucose in body tissues. This uptake occurs following the binding of insulin to its receptors present in the muscle and adipose tissue. The blood glucose lowering effect of insulin also occurs due to the simultaneous inhibition of glucose output from the liver.
Pharmacokinetics: Insulin has a half-life of a few minutes in the blood stream. Consequently, the time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. As with all insulin preparations, the onset of action, intensity and duration of action of isophane insulin human suspension-NPH/Winsulin-30/70/Insulin human Regular is dependent on the dose, site of injection, blood supply, temperature and physical activity.
An average action profile after subcutaneous injection indicates: Onset: within 1-2 hours (Winsulin-N), 0.5 hours (Winsulin-30/70), within 30 minutes (Winsulin-R); Peak levels attained: between 6-12 hours (Winsulin-N), 2-12 hours (Winsulin-30/70), between 1-3 hours (Winsulin-R); Duration of action: approximately 16-18 hours (Winsulin-N/Winsulin-30/70), approximately 6-8 hours (Winsulin-R).