Voriconazole Kabi Caution For Usage

Incompatibilities: Voriconazole Kabi 200 mg must not be infused into the same line or cannula concomitantly with other intravenous products. When the Voriconazole Kabi 200 mg infusion is complete, the line may be used for administration of other intravenous products.
Blood products and short-term infusion of concentrated solutions of electrolytes: Electrolyte disturbances such as hypokalaemia, hypomagnesaemia and hypocalcaemia should be corrected prior to initiation of voriconazole therapy (see Dosage & Administration and Precautions). Voriconazole Kabi 200 mg must not be administered simultaneously with any blood product or any short-term infusion of concentrated solutions of electrolytes, even if the two infusions are running in separate lines.
Total parenteral nutrition: Total parenteral nutrition (TPN) need not be discontinued when prescribed with Voriconazole Kabi 200 mg, but does need to be infused through a separate line. If infused through a multiple-lumen catheter, TPN needs to be administered using a different port from the one used for Voriconazole Kabi 200 mg. Voriconazole Kabi 200 mg must not be diluted with 4.2% Sodium Bicarbonate Infusion. Compatibility with other concentrations is unknown.
This medicinal product must not be mixed with other medicinal products except those mentioned in Special precautions for disposal and other handling as follows.
Special precautions for disposal and other handling: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
The powder is reconstituted with either 19 ml of water for injections or 19 ml of 9 mg/ml (0.9%) Sodium Chloride for Infusion to obtain an extractable volume of 20 ml of clear concentrate containing 10 mg/ml of voriconazole. Discard the Voriconazole Kabi 200 mg vial if vacuum does not pull the diluent into the vial. It is recommended that a standard 20 ml (non-automated) syringe be used to ensure that the exact amount (19.0 ml) of water for injections or (9 mg/ml [0.9%]) Sodium Chloride for Infusion is dispensed. This medicinal product is for single use only and any unused solution should be discarded. Only clear solutions without particles should be used.
For administration, the required volume of the reconstituted concentrate is added to a recommended compatible infusion solution (detailed in the table as follows) to obtain a final voriconazole solution containing 0.5-5 mg/ml. (See Table 10.)

Click on icon to see table/diagram/image

The reconstituted solution can be diluted with: 0.9% Sodium Chloride Intravenous Infusion; Compound Sodium Lactate Intravenous Infusion; 5% Glucose and Compound Sodium Lactate Intravenous Infusion; 5% Glucose and 0.45% Sodium Chloride Intravenous Infusion; 5% Glucose Intravenous Infusion; 5% Glucose in 20 mEq Potassium Chloride Intravenous Infusion; 0.45% Sodium Chloride Intravenous Infusion; 5% Glucose and 0.9% Sodium Chloride Intravenous Infusion.
The compatibility of voriconazole with diluents other than described previously or in Incompatibilities is unknown.