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Hepatotoxicity: Hepatic function abnormalities including liver injury have been reported in clinical studies (see Adverse Reactions). Post marketing reports have also been received in patients treated with vonoprazan, many of which occurred shortly after initiation of treatment, Discontinuation of vonoprazan is recommended in patients who have evidence of liver function abnormalities or if they develop signs or symptoms suggestive of liver dysfunction.
Elevation of intragastric pH: Administration of vonoprazan results in elevation of intragastric pH and is therefore not recommended to be taken with drugs for which absorption is dependent on acidic intragastric pH. (See Interactions).
Symptomatic response to vonoprazan does not preclude the presence of gastric malignancy.
Drug Abuse and Dependence: Vonoprazan has no known potential for abuse or dependence.
Effects on the Ability to Drive and Use Machines: The influence of vonoprazan on the ability to drive or use machines is unknown.
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