Viglaz Drug Interactions

Vildagliptin has low potential for drug interactions. Since Vidagliptin is not a cytochrome P (CYP) 450 enzyme substrate nor does it inhibit or induce CYP450 enzymes, it is not likely to interact with co-medications that are substrates, inhibitors or inducers of these enzymes.
Vildagliptin does not affect metabolic clearance of co-medications metabolized by CYP 1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP 2E1 and CYP 3A4/5. No clinically relevant interactions with other oral antidiabetics (glibenclamide, pioglitazone, metformin), amlodipine, digoxin, ramipril, simvastatin, valsartan or warfarin were observed after co-administration with Vildagliptin.
There may be an increased risk of angioedema in patients concomitantly taking ACE-inhibitors. A greater proportion of cases were reported when Vildagliptin was administered in combination with an angiotensin converting enzyme inhibitor (ACE-Inhibitor). The majority of events were mild in severity and resolved with ongoing Vildagliptin treatment.
As with other oral antidiabetic medicinal products the hypoglycaemic effect of Vildagliptin may be reduced by certain active substances, including thiazides, corticosteroids, thyroid products and sympathomimetics.