Vermectin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing Local Product Insert

Concise Prescribing Info

Contents

Ivermectin

Indications/Uses

Tab: Intestinal strongyloidiasis caused by Strongyloides stercoralis. Soln for inj: Disseminated strongyloides infection (strongyloidiasis) in patient who cannot take tab dosage form.

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Dosage/Direction for Use

Tab Approx 200 mcg/kg as single dose. Patient weighing ≥80 kg 200 mcg/kg, 66-79 kg 2½ tab, 51-65 kg 2 tab, 36-50 kg 1½ tab, 25-35 kg 1 tab, 15-24 kg ½ tab. Soln for inj SC 200 mcg/kg daily.

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Overdosage

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Administration

Tab: Should be taken on an empty stomach.

Contraindications

Hypersensitivity.

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Special Precautions

Not recommended in patients w/ impaired blood-brain barrier (eg, meningitis, African trypanosomiasis) or CNS disorders that may increase drug penetration into CNS. Increased brain conc of ivermectin or increased sensitivity to drug's effects leading to neurotoxicity. Perform repeated stool exam. Consider suppressive treatment (ie, once mthly) in immunocompromised (eg, HIV-infected) patients. Not to be used during pregnancy. Lactation. Not recommended in childn <2 yr or weighing <15 kg. Elderly (greater frequency of decreased hepatic, renal, &/or cardiac function, & of concomitant disease & drug therapy).

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Use In Pregnancy & Lactation

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Adverse Reactions

Facial & peripheral edema, orthostatic hypotension, tachycardia; dizziness; dermatological reaction (including edema, urticarial rash), pruritus; diarrhea, nausea; decreased WBC count, eosinophilia, increased Hb; increased serum ALT & AST. SJS, TEN.

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Drug Interactions

Not recommended in concurrent use w/ γ-aminobutyric acid-potentiating activity eg, barbiturates, benzodiazepines, Na oxybate, valproic acid. May potentiate activity of benzodiazepines. Concomitant use w/ P-gp inhibitors (eg, amiodarone, carvedilol, clarithromycin, cyclosporine, erythromycin, itraconazole, ketoconazole, quinidine, ritonavir, tamoxifen, verapamil) or inducers (eg, amprenavir, clotrimazole, phenothiazines, rifampin, ritonavir, St. John's wort). Elevated INR w/ warfarin.

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Storage

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Description

View Vermectin description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Anthelmintics

ATC Classification

P02CF01 - ivermectin ; Belongs to the class of avermectine agents. Used as antinematodal.

Thai FDA Category

Presentation/Packing

Form

Vermectin soln for inj 10 mg/mL

Packing/Price

2 mL x 10 × 1's;2 mL x 25 × 1's;2 mL x 50 × 1's

Form

Vermectin tab 6 mg

Packing/Price

2 × 6's

Vermectin

ivermectin

Manufacturer:

Atlantic Lab

Distributor:

Atlantic Pharma