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Aescin may enhance the effects of anticoagulants.
The concomitant administration of antibiotics of the aminoglycoside type (e.g. gentamicin) should be avoided, since it cannot totally be ruled out that their nephrotoxicity may be enhanced.
The binding of aescin to plasma proteins may be affected by antibiotics. Cephalotin and ampicillin, e.g. cause a rise in the concentration of free serum aescin.
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