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Pharmacology: Pharmacodynamics: Urea increases the water content of the stratum corneum, result of the hygroscopic characteristics. The drug has also keratolytic action involved alterations in prekeratin and keratin, leading to increased solubilization. In addition, urea break hydrogen bonds that keep the stratum corneum intact.
Pharmacokinetics: Urea is absorbed percutaneously. It is distributed in the extracellular space and excreted in urine. Urea is a natural metabolism, and systemic toxicities with topical application do not occur.
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