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Methotrexate is a folic acid antagonist and is classified as an antimetabolite cytotoxic agent.
Methotrexate is used in the treatment of adults with severe, active, rheumatoid arthritis who are unresponsive or intolerant to conventional therapy.
Methotrexate is indicated for the treatment of pediatric patients with Polyarticular Juvenile Idiopathic Arthritis.
Methotrexate has also been used in the treatment of severe, psoriasis, which is not responsive to other therapy.
Methotrexate has been used to produce regression in a wide range of neoplastic conditions including acute leukaemias, non-Hodgkin's lymphoma, soft-tissue and osteogenic sarcomas, and solid tumours particularly breast, lung, head and neck, bladder, cervical, ovarian, and testicular carcinoma.
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