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TPIAO therapy should be given under direct medical supervision. The administration, dose and course of treatment should be adjusted according to the different disease. The following administration is recommended: When patient with malignant solid tumor receives chemotherapy, and the dosage of drug is predicted to induce thrombocytopenia and hemorrhage, then TPIAO shall be given by subcutaneous injection in 6 to 24 hours after chemotherapy. The dose is 300U/kg bodyweight once per day by subcutaneous injection for 14 continuous days.
The administration shall be stopped when the platelet count recovers to ≥ 100x109/L during the process of administration or the absolute increment of platelet count is ≥ 50x109/L. If anemia or leukopenia associated with chemotherapy occurs, TPIAO shall be used respectively in combination with rhEPO or rhG-CSF.
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