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Concomitant use of etoricoxib and warfarin has resulted in increased serum concentration of warfarin.
Concomitant administration of etoricoxib with rifampicin, a potent inducer of CYP isoenzymes has produced decreased plasma concentrations of etoricoxib.
Concomitant use of etoricoxib and diuretics, angiotensin converting enzyme (ACE) inhibitors and angiotensin II antagonists (AIIAs) may decrease the antihypertensive effect.
Etoricoxib is an inhibitor of human sulfotransferase activity and has been shown to increase the plasma concentration of ethinylestradiol.
