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Pharmacotherapeutic group: Antithrombotic agent, heparin group. ATC code: B01AB05.
Pharmacology: Pharmacodynamics: Mechanism of action: Enoxaparin is a low molecular weight heparin having a small effect on the activated partial thromboplastin time (aPTT) and strongly inhibit factor Xa.
Pharmacodynamic effects: Onset of action: peak effect: Subcutaneous: anti-Xa and antithrombin (anti-IIa): 3 to 5 hours.
Duration: 40 mg dose: Anti-Xa activity: ~12 hours.
Pharmacokinetics: Enoxaparin is rapidly and almost completely absorbed after subcutaneous injection with a bioavailability of about 100%. Peak plasma activity occurs within 1 to 5 hours. The elimination half-life is about 4 to 5 hours but anti-Xa activity may persist for up to 24 hours after a 40 mg dose.
Elimination is prolonged in patients with renal impairment. Enoxaparin is metabolised in the liver and excreted in the urine, as unchanged drug and metabolites.
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