SEVERE, LIFE-THREATENING HUMAN BIRTH EFFECTS.
If thalidomide is taken during pregnancy, it can cause severe birth defects or death to an unborn baby. Thalidomide should never be used by women who are pregnant or who could become pregnant while taking the drug. Even a single dose taken by a pregnant woman during her pregnancy can cause severe birth defects.
Before starting treatment, patients have read and signed the informed consent form for female/male patients for taking THADO and are willing to comply with the constructions and will follow physicians' directions before taking thalidomide. Once treatment has started, if the patient is unable or unwilling to comply with the constructions or directions, they have to stop taking THADO and inform their doctors.
The most serious toxicity associated with thalidomide is its documented human teratogenicity, including phocomelia and death to the fetus. If pregnant women take the drug in 35 to 50 days after last menstrual period, even one single dose could cause severe birth defects.
Thalidomide is common to cause peripheral neuropathy. Peripheral neuropathy generally occurs following chronic use over a period of months, however, reports following relatively short-term use also exist. Symptoms include numbness of toes and feet, tingling or pain in the hands and feet, symmetrical sensorimotor neuropathy, slightly orthostatic tremor uncontrolled ankle cramps, nails crumbly and red palm. Stop therapy with mild symptom appearance and then patients will completely recover soon. If continue therapy with symptom appearance, numbness will become permanent and expand to legs. The possible mechanism of peripheral neuropathy may be the degeneration of neuroxon and sensory nerve fibers of legs will be first affected.
The drug is harmful thus patient must use under physician order.
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