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It has been reported that single oral doses of erlotinib up to 1,000 mg in healthy subjects, and up to 1,600 mg given as a single dose once weekly in cancer patients, have been tolerated. Repeated twice daily doses of 200 mg in healthy subjects were poorly tolerated after only a few days of dosing. Based on the data from these studies, severe adverse reactions such as diarrhea, rash and possibly liver transaminase elevation may occur above the recommended dose.
In case of suspected overdose, erlotinib should be withheld and symptomatic treatment administered.
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