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Pharmacology: Levodopa: On oral administration, levodopa is rapidly converted to dopamine in extracerebral tissues. Only large doses of levodopa (if given alone) are effective since only a small portion of it penetrates unchanged into the brain.
Carbidopa: This is an inhibitor of dopa decarboxylase present in peripheral tissues. Its administration with levodopa prevents unnecessary peripheral decarboxylation of levodopa. Thus, Syndopa 275 reduces the amount of levodopa required by about 75% and increases both plasma levels and the plasma half-life of levodopa.
Mechanism of Action: Symptoms of Parkinson's disease are currently believed to be attributed to depletion of dopamine in the corpus striatum. Levodopa (in Syndopa) is the metabolic precursor of dopamine which crosses the blood-brain barrier and is converted in basal ganglia to the active metabolite. The dopamine thus available relieves the symptoms of Parkinson's disease.
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