Survanta Description

SURVANTA Intratracheal Suspension is supplied in single-use glass vials. Each milliliter contains 25 mg of phospholipids suspended in 0.9% sodium chloride solution. The color is off-white to light brown.
SURVANTA Intratracheal Suspension is a sterile, non-pyrogenic pulmonary surfactant and natural bovine lung extract. It is supplemented with three synthetically derived lipids and surfactant-associated proteins to which colfosceril palmitate (dipalmitoylphosphatidylcholine); palmitic acid and tripalmitin are added to standardize the composition and to mimic surface-tension lowering properties of natural lung surfactant. The resulting composition provides an average concentration of 25 mg/ml phospholipids and less than 1.0 mg/ml protein. The formulation is an off-white to light brown opaque liquid.
Chemistry: The following are the specified ranges for the lipid and protein components of SURVANTA.
Total Phospholipids: approximately 25 mg/ml.
Free Fatty Acids: 1.4 to 3.5 mg/ml.
Triglycerides: 0.5 to 1.75 mg/ml.
Protein: 0.1 to 1.0 mg/ml.
The components are suspended in 0.9% sodium chloride solution and heat-sterilized. SURVANTA contains no preservatives. Its protein content consists of two hydrophobic, low molecular weight, surfactant-associated proteins commonly known as SP-B and SP-C. It does not contain the hydrophilic, large molecular weight, surfactant-associated protein known as SP-A.