Sojourn Dosage/Direction for Use

The concentration of sevoflurane being delivered from a vaporizer during anesthesia should be known. This may be accomplished by using a vaporizer calibrated specifically for sevoflurane. The administration of general anesthesia must be individualized based on the patient's response.
Replacement of Desiccated CO₂ Absorbents: When a clinician suspects that the CO₂ absorbent may be desiccated, it should be replaced. The exothermic reaction that occurs with sevoflurane and CO₂ absorbents is increased when the CO₂ absorbents become desiccated, such as after an extended period of dry gas flow through the CO₂ absorbent canisters (see Precautions).
Pre-Anesthetic Medication: No specific pre-medication is either indicated or contraindicated with sevoflurane. The decision as to whether or not to pre-medicate and the choice of pre-medication is left to the discretion of the anesthesiologist.
Induction: Sevoflurane has a non-pungent odor and does not cause respiratory irritability; it is suitable for mask induction in pediatrics and adults.
Maintenance: Surgical levels of anesthesia can usually be achieved with concentrations of 0.5-3% sevoflurane with or without the concomitant use of nitrous oxide, Sevoflurane can be administered with any type of anesthesia circuit. (See Table 9.)

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