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Pharmacology: Pharmacodynamics: Triamcinolone is a synthetic glucocorticoid. The anti-inflammatory effect of triamcinolone 4 mg is approximately equivalent to hydrocortisone 20 mg, cortisone 25 mg, prednisone/prednisolone 5 mg and methylprednisolone 4 mg. Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
Pharmacokinetics: Triamcinolone is readily absorbed from GI tract. It has a volume distribution of 99.5 L and protein binding of approximately 68%. Triamcinolone is substrate of CYP3A4 (minor).
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